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Current clinical guidelines recognize that the use of more than one agent is necessary to achieve target BP in the majority of patients.
The primary outcomes were the mean change in BP from baseline and the proportion of patients achieving adequate BP control (≤ 140/90 mm Hg, or ≤ 130/80 mm Hg in patients with diabetes mellitus) in the intent-to-treat (ITT) population.
Secondary analyses included incidence of adverse events (ITT) and treatment adherence rate (completers).
In total, 1250 patients comprised the ITT population: 32.6% with newly diagnosed hypertension; 40.5% with hypertension uncontrolled with monotherapy; and 26.9% with hypertension inadequately managed with another combination therapy.
Mean SBP/DBP decreased significantly from baseline (167.4±15.2/101.4±9.1 mm Hg) over 60 days (−41.9 ± 34.8/−23.2 ± 21.8 mm Hg; p Fixed combination perindopril/amlodipine was found to be an effective and well tolerated antihypertensive treatment, with an excellent rate of treatment adherence in the clinical setting.
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