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Current clinical guidelines recognize that the use of more than one agent is necessary to achieve target BP in the majority of patients.

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The primary outcomes were the mean change in BP from baseline and the proportion of patients achieving adequate BP control (≤ 140/90 mm Hg, or ≤ 130/80 mm Hg in patients with diabetes mellitus) in the intent-to-treat (ITT) population.

Secondary analyses included incidence of adverse events (ITT) and treatment adherence rate (completers).

In total, 1250 patients comprised the ITT population: 32.6% with newly diagnosed hypertension; 40.5% with hypertension uncontrolled with monotherapy; and 26.9% with hypertension inadequately managed with another combination therapy.

Mean SBP/DBP decreased significantly from baseline (167.4±15.2/101.4±9.1 mm Hg) over 60 days (−41.9 ± 34.8/−23.2 ± 21.8 mm Hg; p Fixed combination perindopril/amlodipine was found to be an effective and well tolerated antihypertensive treatment, with an excellent rate of treatment adherence in the clinical setting.

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